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IGNOU MZO-05 (January 2025 – December 2025) Assignment Questions

1. Give a broad overview of the organization of viral genomes.

2. Describe the two repeat elements, LINE and SINE with proper diagrams.

3. Describe the different methods for locating genes in a genome sequence.

4. Discuss the principle, methodology and advantages of RNA Sequencing.

5. Given an outline of the chemical sequencing method of DNA with proper illustrations.

6. Discuss the different methods for the prediction of specific domains in proteins.

7. Discuss the different types of ion detectors in mass spectrometry.

8. Give a broad overview of Bacterial Artificial Chromosome and Yeast Artificial Chromosome.

9. Highlight the different applications of RNA interference technology.

10. Write short notes:

a) Yeast two-hybrid system

b) Suppression subtractive hybridization

c) Phage display for DNA binding proteins

d) Chemical ionization in mass spectrometry

IGNOU MZO-05 (January 2024 – December 2024) Assignment Questions

1. What are introns and exons? Discuss the evolution of proteins by exon shuffling with illustrations.

2. Discuss with diagrams the different types of repeat elements present in eukaryotic genomes.

3. What is genome sequencing? Give an overview of the two broad types of genome sequencing you have studied.

4. Write short notes:

a) Multiple sequence alignment
b) cDNA-AFLP

5. Outline the basic principles of Northern blotting and GeneCalling.

6. What is peptide sequencing? Discuss with schematic representation, Edman degradation method of peptide sequencing. Mention its advantages and disadvantages.

7. Elaborate the different methods used for ionization of proteins during mass spectrometry.

8. Write an account on the Human Genome Project, with special reference to the analysis, recent advances and importance in medical sciences.

9. What is meant by gene silencing? Discuss the components of gene silencing. Write an account of homology-dependent gene silencing.

10. Describe with proper diagrams, the technique of Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and its applications.

MZO-05 Assignments Details

University	:	IGNOU (Indira Gandhi National Open University)
Title	:	Genomics and Proteomics
Language(s)	:	English
Code	:	MZO-05
Degree	:	MSCZOO
Subject	:	Zoology
Course	:	Core Courses (CC)
Author	:	Gullybaba.com Panel
Publisher	:	Gullybaba Publishing House Pvt. Ltd.